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Cobimetinib in phase 3 for metastatic melanoma

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Cobimetinib

934660-93-2  cas

[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl} methanone

l-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-[(2S)-piperidin-2- yl]azetidin-3-ol

1-[3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)phenyl]-1-[3-hydroxy-3-[2(S)-piperidinyl]azetidin-1-yl]methanone

Cobimetinib, XL518, GDC 0973, 934660-93-2, XL…

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MIT chemists design nanoparticles that can deliver three cancer drugs at a time.

MIT chemists design nanoparticles that can deliver three cancer drugs at a time.

Targeting Cancer with a Triple Threat | MIT Technology Review MIT chemists design nanoparticles that can deliver three cancer drugs at a time.

Delivering chemotherapy drugs in nanoparticle form could help reduce side effects by targeting the drugs directly to the tumors. In recent years, scientists have developed nanoparticles that deliver one or two chemotherapy drugs, but it has been…

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Antimalarials………….Arterolane from Ranbaxy

Antimalarials………….Arterolane from Ranbaxy

Originally posted on New Drug Approvals:

Arterolane.png664338-39-0   Arterolane 664338-39-0, UNII-3N1TN351VB, OZ277, RBX-11160, NCGC00274173-01 Molecular Formula: C22H36N2O4 Medicines For Malaria Venture Mmv Ranbaxy Lab Ltd  Molecular Weight: 392.53224  cis-adamantane-2-spiro-3’-8’-[[[(2’-amino-2’ methylpropyl) amino] carbonyl] methyl] 1’,2’,4’-trioxaspiro [4.5] decane…

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ACT-280778 is a L/T calcium channel blocker potentially indicated for the treatment of hypertension and angina pectoris

ACT-280778 is a L/T calcium channel blocker potentially indicated for the treatment of hypertension and angina pectoris

Originally posted on New Drug Approvals:

Abstract Image ACT-280778

(1R,2R,4R)-2-(2-((3-(4,7-Dimethoxy-1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-5-phenylbicyclo[2.2.2]oct-5-en-2-yl Isobutyrate

Propanoic acid, 2-​methyl-​, (1R,​2R,​4R)​-​2-​[2-​[[3-​(4,​7-​dimethoxy-​1H-​benzimidazol-​2-​yl)​propyl]​methylamino]​ethyl]​-​5-​phenylbicyclo[2.2.2]​oct-​5-​en-​2-​yl ester

isobutyric acid…

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ACT-280778 is a L/T calcium channel blocker potentially indicated for the treatment of hypertension and angina pectoris

ACT-280778, is a L/T calcium channel blocker potentially indicated for the treatment of hypertension and angina pectoris

Abstract Image ACT-280778

(1R,2R,4R)-2-(2-((3-(4,7-Dimethoxy-1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-5-phenylbicyclo[2.2.2]oct-5-en-2-yl Isobutyrate

Propanoic acid, 2-​methyl-​, (1R,​2R,​4R)​-​2-​[2-​[[3-​(4,​7-​dimethoxy-​1H-​benzimidazol-​2-​yl)​propyl]​methylamino]​ethyl]​-​5-​phenylbicyclo[2.2.2]​oct-​5-​en-​2-​yl ester

isobutyric acid…

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More and more companies are using fragment-based lead design as a drug discovery strategy

More and more companies are using fragment-based lead design as a drug discovery strategy

8629cov_opencxd_opt shaking hands Small fragments that bind in nearby pockets can be connected to make a lead.

In the pursuit of new pharmaceuticals, many medicinal chemists want to start their leg of the drug discovery race with a drug-sized molecule that binds with a tenacious grip—we’re talking nanomolar potency—to its biological target. After all, there are so many molecular traits to optimize, such as…

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