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PRANLUKAST

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Antiasthmatic. Launched – 1995 japan150821-03-7, C27 H23 N5 O4 . H2O, 499.5179 103177-37-3 anhydrous, 103180-28-5 (monosodium salt) Ono-1078
Ono-RS-411
RS-411
SB-205312
Ono-1070 (monosodium salt) N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide hemihydrate Ono (Originator)Schering-Plough (Licensee)………. J Med Chem 1988, 31(1): 84, WO 2010002075, Synth…

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Evaluation of Pd-catalyzed hydrogenations under flow conditions

Evaluation of Pd-catalyzed hydrogenations under flow conditions

Originally posted on SynthFlow:

Just finished reading an excellent example from a group in Japan moving a batch hydrogenation to flow. Dr Sajiki’s group developed and evaluated a number of Pd-catalysts and their effectiveness in an H-Cube (Thales Nano) reactor. This evaluation went into detail on both reaction optimization and chemoselectivities, depending on the catalyst type — while scoping a…

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DRUG SPOTLIGHT…MONTELUKAST

DRUG SPOTLIGHT…MONTELUKAST

MONTELUKAST SODIUM MK-0476 (Montelukast, L-706631) US 8,007,830, US 5,565,473*PED, MERCK NDA 021409  APPR Jul 26, 2002 MONTELUKAST (Singulair® Oral Granules) helps to reduce asthma symptoms (coughing, wheezing, shortness of breath, or chest tightness) and control your asthma. It does not provide instant relief and cannot be used to treat a sudden asthma attack. It works only when used on a…

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USV Limited , WO 2014167577 Synthesis of dabigatran….NEW PATENT FEATURE ON NEWDRUGAPPROVALS

USV Limited , WO 2014167577 Synthesis of dabigatran….NEW PATENT FEATURE ON NEWDRUGAPPROVALS

USV Limited

http://www.usvindia.com/

16-Oct-2014        pub date

WO-2014167577-A2
Title of the invention: “”SYNTHESIS OF DABIGATRAN”.”

Applicants: USV LIMITED (IN).

Inventors: Laxmikant Narhari Patkar (IN), Harish Kashinath Mondkar (IN), Sachin Shivaji Patil (IN), Tanaji Shamrao Jadhav (IN), Nitin Nivrutti Hagavane (IN), Rajesh Ganpat Bopalkar (IN) and Nitin Dnyaneshwar Arote (MY).

 

The…

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Advanced Intermediate Flow Studies: Nevirapine

Advanced Intermediate Flow Studies: Nevirapine

Originally posted on SynthFlow:

After looking through a number of flow articles that describe and illustrate processes toward the production of drug final products and advanced intermediates, I thought an articlefrom Florida State — Tyler McQuade (open source Beilstein JOC 2013) was informative and storytelling. He was able to show some of the challenges that go into designing a flow methodology…

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