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ETHYL PROPIONATE NMR, carbonyl is dad and oxygen mom, a methyl gets more attention

ETHYL PROPIONATE NMR, carbonyl is dad and oxygen mom, a methyl gets more attention

Dedicated to all moms

C=O group is dad

O atom is mom

 

Carbonyl is dad and oxygen mom hence c labelled methyl has higher chemical shift  and gets a little more attention

SEE BELOW

NMR IS EASY

A chemical has Formula: C5H10O2

C5H10O2
Rule 2, omit O, gives C5H10
5 – 10/2 + 1 = 1 degree of unsaturation.
Look for 1 pi bond or aliphatic ring.

IR

IR spectrum

 

The band at 1740 indicates a carbonyl,…

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A set of reaction conditions for an asymmetric Michael addition that isn’t hard to PEG

A set of reaction conditions for an asymmetric Michael addition that isn’t hard to PEG

Originally posted on Developing the Process:

If I can get away with a pun or a witty title for a tweet, I will try to do it.  I have been posting a lot of older material from my former website, PHARMNBIOFUEL.COM due to the fact that I have been keeping myself busy on other projects, plus I ran out of articles to talk about.  I usually take the bus into the city, take a few hours peruse some of…

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Sage Therapeutics receives fast track designation for status epilepticus therapy

Sage Therapeutics receives fast track designation for status epilepticus therapy

SAGE-547

Sage Therapeutics (Originator)

For Epilepsy, status epilepticus

Sage Therapeutics receives fast track designation for status epilepticus therapy
Ligand Pharmaceuticals announced that its partner Sage Therapeutics has received fast track designation from the US Food and Drug Administration (FDA) for the Captisol-enabled SAGE-547 to treat status epilepticus.

read at

http://www…

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FDA Approves Ryanodex for the Treatment of Malignant Hyperthermia

FDA Approves Ryanodex for the Treatment of Malignant Hyperthermia

Dantrolene Tanaka et al.svg

Dantrolene sodium

1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione

FDA Approves Ryanodex for the Treatment of Malignant Hyperthermia

WOODCLIFF LAKE, N.J.(BUSINESS WIRE) July 23, 2014 — Eagle Pharmaceuticals, Inc. (“Eagle” or “the Company”) (Nasdaq:EGRX) today announced that the U. S. Food and Drug Administration (FDA) has approved Ryanodex (dantrolene sodium) for…

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FDA Approves Ryanodex for the Treatment of Malignant Hyperthermia

FDA Approves Ryanodex for the Treatment of Malignant Hyperthermia

Dantrolene Tanaka et al.svg

Dantrolene sodium

1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione

FDA Approves Ryanodex for the Treatment of Malignant Hyperthermia

WOODCLIFF LAKE, N.J.(BUSINESS WIRE) July 23, 2014 — Eagle Pharmaceuticals, Inc. (“Eagle” or “the Company”) (Nasdaq:EGRX) today announced that the U. S. Food and Drug Administration (FDA) has approved Ryanodex (dantrolene sodium) for…

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Best practice paper on visual inspection to be published in September 2014

Best practice paper on visual inspection to be published in September 2014

 

 

Best practice paper on visual inspection to be published in September 2014

The ECA working group on visual inspection, which was founded this year, is going to publish its first document during the ECA event Particles in Parenterals and beyond. Read more.

http://www.gmp-compliance.org/eca_mitt_4410_8398,Z-PEM_n.html 

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Every fifth FDA Warning Letter includes deficiencies regarding Equipment

Every fifth FDA Warning Letter includes deficiencies regarding Equipment

Originally posted on New Drug Approvals:

Every fifth FDA Warning Letter includes deficiencies regarding Equipment

The considered period from 2012 until the first quarter of 2014 pertains to both companies in and outside of the United States.

None of the 19 mentioned warning letters is solely due to deficiencies regarding equipment. However, the big picture shows the lack of understanding of…

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    Every fifth FDA Warning Letter includes deficiencies regarding Equipment In 19 of the…

Every fifth FDA Warning Letter includes deficiencies regarding Equipment In 19 of the total of 92 warning letters of the last two years, shortcomings regarding equipment are part of the complaints. The most commonly cited issues are maintenance (including calibration), cleaning and the qualification of equipment. Read more.  

http://www.gmp-compliance.org/enews_4361_Every%20fi…

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